WebThe isomerization reaction moves the carbonyl group to C‑2, thus making it a nucleophile that can attack C‑3 to generate two three‑carbon sugars. - Breaking a C−C bond is energetically unfavorable and can only proceed if a functional group with electronegative atoms is adjacent to the cleavage site to stabilize the reaction intermediates. The Bürgi–Dunitz angle (BD angle) is one of two angles that fully define the geometry of "attack" (approach via collision) of a nucleophile on a trigonal unsaturated center in a molecule, originally the carbonyl center in an organic ketone, but now extending to aldehyde, ester, and amide carbonyls, and to alkenes (olefins) as well. The angle was named after crystallographers Hans-Beat Bürgi and Jack D. Dunitz, its first senior investigators.
Bürgi–Dunitz angle - Wikipedia
WebJul 20, 2024 · The electrophilic carbon atom of aldehydes and ketones can be the target of nucleophilic attack by amines as well as alcohols. The end result of attack by an amine … WebThe slightly positive carbon atom in the carbonyl group can be attacked by nucleophiles. A nucleophile is a negatively charged ion (for example, a cyanide ion, CN … hih gruppe hamburg
17.5: Reactivity of the Carbonyl Group: Mechanisms of Addition
WebJan 23, 2024 · The basic reaction involves the nucleophilic attack of the carbanionic carbon in the organometallic reagent with the electrophilic carbon in the carbonyl … WebThe carbonyl carbon is electrophilic and can undergo nucleophilic attack by carbon, oxygen, sulfur and nitrogen-containing nucleophiles. In this tutorial, we will focus on oxygen-containing nucleophiles, which form hydrates, hemiacetals and acetals. WebOct 6, 2024 · The nucleophile then attacks the carbonyl group opposite the larger of the two remaining groups (i.e., the medium group). This is best explained with a diagram: In the reduction of ( S )-3-phenylbutan-2-one with L-Selectride (a bulky source of hydride ion), the anti alcohol is formed as the major diastereomer. hih-gruppe wikipedia