Paclitaxel resistance
WebFeb 27, 2006 · Resistance to paclitaxel in laboratory cell line models has been extensively explored, and various mechanisms of resistance have been identified ( 4 – 6 ). One reported mechanism is the overexpression of ABC transporters, including P-glycoprotein/MDR1/ABCB1, ABCB4 (MDR2), ABCB11 (BSEP and SPGP; ref. 7 – 9 ), and … WebFeb 27, 2006 · Abstract. Resistance to paclitaxel-based therapy is frequently encountered in the clinic. The mechanisms of intrinsic or acquired paclitaxel resistance are not well …
Paclitaxel resistance
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WebNov 1, 2016 · To address this issue, we established paclitaxel-resistant sublines of the SK-BR-3 and MCF-7 breast cancer cell lines that are capable of long-term proliferation in … WebJan 1, 2024 · Mechanisms of paclitaxel resistance by cancer cells have yet to be fully elucidated. One of the recent reviews broadly described the paclitaxel resistance mechanism in cancer cell caused by MDR efflux transporters overexpression, altered expression of microtubule-associated proteins or microtubule alternation (Das et al., …
WebAug 23, 2024 · Platinum plus paclitaxel is a first-line chemotherapy for ovarian cancer. Platinum resistance is a hot topic for many scholars, but drug resistance caused by paclitaxel is also a topic of concern. Currently, scholars believe that inhibition of MAPK signaling pathway may be an effective way to reverse the drug resistance of tumor … WebDec 14, 2024 · Paclitaxel (PTX) is heavily relied on as a frontline chemotherapy drug in breast cancer treatment, especially in advanced metastatic cancer. Generation of …
WebDec 16, 2024 · Paclitaxel has been used widely to treat breast cancer and other types of cancer. However, resistance is a major cause of failure for treatment and results in … WebWe used GEO data to generate paclitaxel resistance in two basal-like TNBC cell lines (SUM149 and MDA-MB-468). Seventy-one common upregulated differentially expressed genes (DEGs) and 11 downregulated DEGs were found to be related to paclitaxel resistance. By constructing protein-protein interactions, 28 hub proteins with a degree …
WebOct 9, 2024 · Abstract We investigated the molecular mechanisms of paclitaxel resistance in TNBC using seven patient-derived xenograft (PDX) models and TNBC cell lines. Among the seven PDX models, four models showed resistance to paclitaxel. Dysregulation of JAK/STAT pathways and JAK2 copy number gains were observed in the four paclitaxel …
WebAug 4, 2024 · Circular RNAs (circRNAs) and epithelial to mesenchymal transition (EMT) have been implicated in the development of human cancer and paclitaxel resistance. CircRNA circ_0007534 has been described as a key oncogenic circular RNA that is upregulated in a variety of cancer tissues. However, whether circ_0007534 causes EMT … hate fall memeWebNov 21, 2024 · paclitaxel must be given slowly, and the infusion can take 3 to 24 hours to complete. Paclitaxel is usually given once every 2 to 3 weeks. Follow your doctor's … hatef dastourWebNov 11, 2024 · Paclitaxel is a chemotherapeutic agent that acts as an inhibitor of cellular mitosis and has been widely used in the treatment of triple-negative breast cancer … hate farming onlineWebOct 21, 2024 · PTX resistance mechanisms are different and involve alterations in α- and β-tubulin, increased expression and activity of multidrug resistance (MDR) efflux … hate famous sayingsWebApr 27, 2024 · Identification of ALDH2 as a paclitaxel resistance-related gene in NSCLC cells. We first measured the resistance index (RI) value of the NSCLC/PTX cells to confirm PTX resistance. Results showed that the PTX resistance index of NSCLC/PTX cells is greater than 15 (Fig. S1A). Thus, the cells are highly drug-resistant and can be used in … boots ammanford phone numberWebWe identified that once in the EGFR-TKI persister state, paclitaxel-resistant cells enrich their stemness profile and rewire their glucose metabolism and an apoptotic control … hate farminghate farm psx script